ClinGen Actionability Working Group aims to identify those human genes that, when significantly altered, confer a high risk of serious disease that could be prevented or mitigated if the risk were known.

Goals of ClinGen Actionability Working Group:

  • Develop rigorous and standardized procedures for categorically defining “clinical actionability”; a concept that includes a known ability to intervene and thereby avert a poor outcome due to a previously unsuspected high risk of disease

  • Nominate genes and diseases to score for “clinical actionability”

  • Produce evidence-based reports and semi-quantitative metric scores using a standardized method for nominated gene disease pairs

  • Make these reports and actionability scores publicly available to aid broad efforts for prioritizing those human genes with the greatest relevance for clinical intervention

Adult AWG Reports (Public)

Publicly available AWG generated reports with scores for outcome/interventions for adult subjects can be found here:

Adult AWG Reports

Pediatric AWG Reports (Public)

Publicly available AWG generated reports with scores for outcome/interventions for pediatric subjects can be found here:

Ped AWG Reports

Services available here provide interface to curate data by ClinGen Actionability WG.

Adult Actionability Curation Interface (Login Required)

The curation interface to score outcome/interventions for adult subjects:

Adult ACI

Pediatric Actionability Curation Interface (Login Required)

The curation interface to score outcome/interventions for pediatric subjects:

Ped ACI

Reset Password - If you do not remember your password, you can reset your password using this option. You will then receive a temporary password in your email. Use the temporary password to login to the system and change your password by using the link below.
Change Password - Use this to change your current password.
Services available here are collaborative efforts between ClinGen Actionability Working Group and the Informatics team at Baylor College of Medicine.