ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Mismatch repair cancer syndrome (MMRCS)
Gene/Gene Panel: MLH1, MSH2, MSH6, PMS2
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2024/03/24
Released
1.0.2
P
Morbidity and mortality from neoplasia (GroupA)
Evaluation and multi-modal neoplasia surveillance by specialist(s) to guide treatment (GroupA) 9CN
System migration to fix the sem versioning
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MLH1 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 1; MMRCS1
Moderate Actionability
Strong Actionability
MSH2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 2; MMRCS2
Moderate Actionability
Strong Actionability
MSH6 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 3; MMRCS3
Moderate Actionability
Strong Actionability
PMS2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 4; MMRCS4
Moderate Actionability
Strong Actionability
2024/03/24
Released (Under revision)
P
Morbidity and mortality from neoplasia (GroupA)
Evaluation and multi-modal neoplasia surveillance by specialist(s) to guide treatment (GroupA) 9CN
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MLH1 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 1; MMRCS1
Moderate Actionability
Strong Actionability
MSH2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 2; MMRCS2
Moderate Actionability
Strong Actionability
MSH6 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 3; MMRCS3
Moderate Actionability
Strong Actionability
PMS2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 4; MMRCS4
Moderate Actionability
Strong Actionability
2023/02/01
Released
P
Morbidity and mortality from neoplasia (GroupA)
Evaluation and multi-modal neoplasia surveillance by specialist(s) to guide treatment (GroupA) 9CN
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MLH1 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 1; MMRCS1
Moderate Actionability
Strong Actionability
MSH2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 2; MMRCS2
Moderate Actionability
Strong Actionability
MSH6 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 3; MMRCS3
Moderate Actionability
Strong Actionability
PMS2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 4; MMRCS4
Moderate Actionability
Strong Actionability
2023/01/31
Released (Under revision)
1.0.0
P
Morbidity and mortality from MMRCS-related neoplasia (GroupA)
Evaluation and multi-modal neoplasia surveillance by specialist(s) to guide treatment (GroupA) 9CN
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MLH1 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 1; MMRCS1
Moderate Actionability
Strong Actionability
MSH2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 2; MMRCS2
Moderate Actionability
Strong Actionability
MSH6 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 3; MMRCS3
Moderate Actionability
Strong Actionability
PMS2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 4; MMRCS4
Moderate Actionability
Strong Actionability
2022/12/06
Released
1.0.0
P
Morbidity and mortality from MMRCS-related neoplasia (GroupA)
Evaluation and multi-modal neoplasia surveillance by specialist(s) to guide treatment (GroupA) 9CN
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MLH1 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 1; MMRCS1
Moderate Actionability
Strong Actionability
MSH2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 2; MMRCS2
Moderate Actionability
Strong Actionability
MSH6 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 3; MMRCS3
Moderate Actionability
Strong Actionability
PMS2 ⇔ 0031219 MISMATCH REPAIR CANCER SYNDROME 4; MMRCS4
Moderate Actionability
Strong Actionability
2022/10/26
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
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