ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Multiple Endocrine Neoplasia IIA, Familial Medullary Thyroid Cancer
Gene/Gene Panel: RET
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2022/02/09
Released
1.0.4
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RET ⇔ 0007958 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC
Strong Actionability
Strong Actionability
RET ⇔ 0008234 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A
Strong Actionability
Strong Actionability
2022/02/09
Released (Under revision)
1.0.3
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RET ⇔ 0007958 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC
Strong Actionability
Strong Actionability
RET ⇔ 0008234 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A
Strong Actionability
Strong Actionability
2021/09/13
Released
1.0.3
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RET ⇔ 0007958 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC
Strong Actionability
Strong Actionability
RET ⇔ 0008234 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A
Strong Actionability
Strong Actionability
2021/09/13
Released (Under revision)
1.0.2
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RET ⇔ 0007958 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC
Strong Actionability
Strong Actionability
RET ⇔ 0008234 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A
Strong Actionability
Strong Actionability
2021/09/13
Released
1.0.2
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RET ⇔ 0007958 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC
Strong Actionability
Strong Actionability
RET ⇔ 0008234 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A
Strong Actionability
Strong Actionability
2021/09/01
Released (Under revision)
1.0.1
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Added MONDO IDs.
2020/04/09
Released
1.0.1
P
Hyperparathyroidism (GroupA)
Biochemical surveillance (GroupA) 9CD
Medullary thyroid cancer (GroupA)
Prophylactic Thyroidectomy (GroupA) 9CA
Pheochromocytoma (GroupA)
Biochemical surveillance (GroupA) 10CD
Added MONDO IDs.
2019/10/03
Released (Under revision)
1.0.0
P
Hyperparathyroidism
Biochemical surveillance 9CD
Medullary thyroid cancer
Prophylactic Thyroidectomy 9CA
Pheochromocytoma
Biochemical surveillance 10CD
2019/06/19
Released
1.0.0
P
Hyperparathyroidism
Biochemical surveillance 9CD
Medullary thyroid cancer
Prophylactic Thyroidectomy 9CA
Pheochromocytoma
Biochemical surveillance 10CD
2019/05/13
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
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