ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Li-Fraumeni Syndrome
Gene/Gene Panel: TP53
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2024/03/24
Released
1.0.3
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
System migration to fix the sem versioning
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0018875 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2024/03/24
Released (Under revision)
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0018875 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2023/07/14
Released
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0018875 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2023/07/14
Released (Under revision)
1.0.1
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0007903 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2022/02/09
Released
1.0.1
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0007903 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2022/02/09
Released (Under revision)
1.0.0
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0007903 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2021/07/21
Released
1.0.0
P
Morbidity and mortality from Li Fraumeni syndrome-associated cancers (GroupA)
Avoidance of radiotherapy (GroupA) 8CB
Cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TP53 ⇔ 0007903 LI-FRAUMENI SYNDROME; LFS
Moderate Actionability
Strong Actionability
2020/02/18
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
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