ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Familial Adenomatous Polyposis
Gene/Gene Panel: APC
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2023/06/28
Released
1.0.6
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Internal system migration to amend the actionability rationale with respect to the assertion, definitive actionability.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2023/06/28
Released (Under revision)
1.0.5
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2022/02/09
Released
1.0.5
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2022/02/09
Released (Under revision)
1.0.4
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Link to complimentary ACMG ACT sheet added to "Patient Management" section
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2021/05/06
Released
1.0.4
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Link to complimentary ACMG ACT sheet added to "Patient Management" section
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2021/05/03
Released (Under revision)
1.0.3
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2021/03/29
Released
1.0.3
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
APC ⇔ 0021057 FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1
Strong Actionability
Definitive Actionability
2021/01/06
Released (Under revision)
1.0.2
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/08/17
Released
1.0.2
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/08/17
Released (Under revision)
1.0.1
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/05/04
Released
1.0.1
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/04/30
Released (Under revision)
1.0.0
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/04/29
Released
1.0.0
P
Morbidity and mortality due to colorectal cancer (GroupA)
Colonoscopic surveillance to determine polyp burden and guide (if appropriate) timing of (procto) colectomy (GroupA) 10CA
2020/01/29
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
¤ Powered by BCM's Genboree.