ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Brugada Syndrome
Gene/Gene Panel: SCN5A
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2022/02/09
Released
1.0.2
P
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Risk stratification (may include EPS) to guide ICD placement (GroupA) 9CD
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2022/02/09
Released (Under revision)
1.0.1
P
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Risk stratification (may include EPS) to guide ICD placement (GroupA) 9CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2021/03/29
Released
1.0.1
P
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Risk stratification (may include EPS) to guide ICD placement (GroupA) 9CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2020/12/16
Released (Under revision)
1.0.0
P
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Risk stratification (may include EPS) to guide ICD placement (GroupA) 9CD
2020/05/12
Released
1.0.0
P
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Risk stratification (may include EPS) to guide ICD placement (GroupA) 9CD
2020/04/07
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
¤ Powered by BCM's Genboree.