ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Tuberous Sclerosis Complex (TSC)
Gene/Gene Panel: TSC2, TSC1
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2023/02/21
Released
1.0.1
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Internal system migration to correct the RELEASE VERSION NUMBER.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2023/02/21
Released (Under revision)
..NaN
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/10/20
Released
..NaN
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/10/20
Released (Under revision)
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/10/20
Released
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/10/20
Released (Under revision)
1.0.0
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/06/02
Released
1.0.0
P
Morbidity and mortality from TSC-related lesions (GroupA)
Evaluation by specialist with imaging to guide possible use of mTORi therapy (GroupA) 9CB
Morbidity and mortality from infantile spasms (GroupA)
Evaluation by specialist with testing to guide possible use of vigabatrin (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
TSC1 ⇔ 0001734 TUBEROUS SCLEROSIS 1; TSC1
Strong Actionability
Strong Actionability
TSC2 ⇔ 0001734 TUBEROUS SCLEROSIS 2; TSC2
Strong Actionability
Strong Actionability
2022/04/21
In Preparation
N/A
We have begun assessment of the Pediatric context for this topic
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