ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: DICER1-Related Disorders
Gene/Gene Panel: DICER1
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2024/07/23
Released
1.1.5
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
Replaced the parent MONDO that had been obsoleted.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0100216 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
DICER1 ⇔ 0100216 RHABDOMYOSARCOMA, EMBRYONAL, 2; RMSE2
Assertion Pending
Moderate Actionability
DICER1 ⇔ 0100216 PLEUROPULMONARY BLASTOMA; PPB
Assertion Pending
Moderate Actionability
2024/01/08
Released (Under revision)
1.1.4
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
2022/02/09
Released
1.1.4
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
2022/02/09
Released (Under revision)
1.1.3
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
This release is related to a data system fix.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
2021/08/12
Released
1.1.3
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
This release is related to a data system fix.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
2021/07/28
Released (Under revision)
1.1.2
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
DICER1 ⇔ 0017288 RHABDOMYOSARCOMA, EMBRYONAL, 2; RMSE2
Moderate Actionability
Assertion Pending
DICER1 ⇔ 0017288 PLEUROPULMONARY BLASTOMA; PPB
Moderate Actionability
Assertion Pending
2021/06/16
Released
1.1.2
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DICER1 ⇔ 0017288 GOITER, MULTINODULAR 1, WITH OR WITHOUT SERTOLI-LEYDIG CELL TUMORS; MNG1
Moderate Actionability
Moderate Actionability
DICER1 ⇔ 0017288 RHABDOMYOSARCOMA, EMBRYONAL, 2; RMSE2
Moderate Actionability
Assertion Pending
DICER1 ⇔ 0017288 PLEUROPULMONARY BLASTOMA; PPB
Moderate Actionability
Assertion Pending
2021/05/05
Released (Under revision)
1.1.1
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
2020/04/29
Released
1.1.1
P
Morbidity and mortality from pleuropulmonary blastoma (GroupA)
Chest imaging (GroupA) 8NB
Morbidity and mortality from thyroid carcinoma and other DICER-related cancers (GroupA)
Surveillance (GroupA) 8CD
2019/08/21
Released (Under revision)
1.1.0
P
Morbidity and mortality from pleuropulmonary blastoma
Chest imaging 6DB
Morbidity and mortality from DICER-related cancers
Surveillance 8CB
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
P
Morbidity and mortality from pleuropulmonary blastoma
Chest imaging 6DB
Morbidity and mortality from DICER-related cancers
Surveillance 8CB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.1
P
Morbidity and mortality from pleuropulmonary blastoma
Chest imaging 6DB
Morbidity and mortality from DICER-related cancers
Surveillance 8CB
Internal system migration related to score text replacement from E to N
2018/08/02
Released
1.0.0
P
Morbidity and mortality from pleuropulmonary blastoma
Chest imaging 6DB
Morbidity and mortality from DICER-related cancers
Surveillance 8CB
2018/06/26
In Preparation
N/A
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