ACTIONABILITY KNOWLEDGE REPOSITORY
ACTIONABILITY CURATION INTERFACE
Update History
Condition: POLE and POLD1 associated susceptibility to CRC
Gene/Gene Panel: POLE, POLD1
Context: Adult
2022/07/07
Released
(Under revision)
1.1.4
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
POLE
⇔
0014038 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12
Moderate Actionability
Strong Actionability
POLD1
⇔
0012953 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
Strong Actionability
Strong Actionability
2022/02/09
Released
1.1.4
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
POLE
⇔
0014038 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12
Moderate Actionability
Strong Actionability
POLD1
⇔
0012953 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
Strong Actionability
Strong Actionability
2022/02/09
Released
(Under revision)
1.1.3
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
POLE
⇔
0014038 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12
Moderate Actionability
Strong Actionability
POLD1
⇔
0012953 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
Strong Actionability
Strong Actionability
2021/11/15
Released
1.1.3
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
POLE
⇔
0014038 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12
Moderate Actionability
Strong Actionability
POLD1
⇔
0012953 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
Strong Actionability
Strong Actionability
2021/10/18
Released
(Under revision)
1.1.2
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
2020/04/10
Released
1.1.2
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
2020/04/08
Released
(Under revision)
1.1.1
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Added MONDO IDs
2020/04/08
Released
1.1.1
Colorectal Cancer
(GroupB)
Colonoscopy with polypectomy
(GroupB)
10BB
Colorectal Cancer
(GroupA)
Colonoscopy with polypectomy
(GroupA)
9BB
Added MONDO IDs
2019/10/03
Released
(Under revision)
1.1.0
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.2
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
Internal system migration related to score text replacement from E to N
2018/09/18
Released
1.0.1
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
2018/09/18
Released
(Under revision)
1.0.0
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
2018/09/17
Released
1.0.0
Colorectal Cancer (POLD1)
Colonoscopy with polypectomy
10BB
Colorectal Cancer (POLE)
Colonoscopy with polypectomy
9BB
2018/08/21
In Preparation
N/A