ACTIONABILITY KNOWLEDGE REPOSITORY
ACTIONABILITY CURATION INTERFACE
Update History
Condition: Paragangliomas 1, 2, 3, 4, 5; Pheochromocytoma
Gene/Gene Panel: SDHD
Context: Adult
2026/06/16
Released
(Under revision)
1.1.4
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MAX
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
SDHA
⇔
0017366 PARAGANGLIOMAS 5; PGL5
Strong Actionability
Moderate Actionability
SDHAF2
⇔
0017366 PARAGANGLIOMAS 2; PGL2
Strong Actionability
Strong Actionability
SDHB
⇔
0017366 PARAGANGLIOMAS 4; PGL4
Strong Actionability
Strong Actionability
SDHC
⇔
0017366 PARAGANGLIOMAS 3; PGL3
Strong Actionability
Strong Actionability
SDHD
⇔
0017366 PARAGANGLIOMAS 1; PGL1
Strong Actionability
Strong Actionability
TMEM127
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
2022/02/09
Released
1.1.4
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MAX
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
SDHA
⇔
0017366 PARAGANGLIOMAS 5; PGL5
Strong Actionability
Moderate Actionability
SDHAF2
⇔
0017366 PARAGANGLIOMAS 2; PGL2
Strong Actionability
Strong Actionability
SDHB
⇔
0017366 PARAGANGLIOMAS 4; PGL4
Strong Actionability
Strong Actionability
SDHC
⇔
0017366 PARAGANGLIOMAS 3; PGL3
Strong Actionability
Strong Actionability
SDHD
⇔
0017366 PARAGANGLIOMAS 1; PGL1
Strong Actionability
Strong Actionability
TMEM127
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
2022/02/09
Released
(Under revision)
1.1.3
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MAX
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
SDHA
⇔
0017366 PARAGANGLIOMAS 5; PGL5
Strong Actionability
Moderate Actionability
SDHAF2
⇔
0017366 PARAGANGLIOMAS 2; PGL2
Strong Actionability
Strong Actionability
SDHB
⇔
0017366 PARAGANGLIOMAS 4; PGL4
Strong Actionability
Strong Actionability
SDHC
⇔
0017366 PARAGANGLIOMAS 3; PGL3
Strong Actionability
Strong Actionability
SDHD
⇔
0017366 PARAGANGLIOMAS 1; PGL1
Strong Actionability
Strong Actionability
TMEM127
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
2022/01/03
Released
1.1.3
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
MAX
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
SDHA
⇔
0017366 PARAGANGLIOMAS 5; PGL5
Strong Actionability
Moderate Actionability
SDHAF2
⇔
0017366 PARAGANGLIOMAS 2; PGL2
Strong Actionability
Strong Actionability
SDHB
⇔
0017366 PARAGANGLIOMAS 4; PGL4
Strong Actionability
Strong Actionability
SDHC
⇔
0017366 PARAGANGLIOMAS 3; PGL3
Strong Actionability
Strong Actionability
SDHD
⇔
0017366 PARAGANGLIOMAS 1; PGL1
Strong Actionability
Strong Actionability
TMEM127
⇔
0017366 PHEOCHROMOCYTOMA
Strong Actionability
Strong Actionability
2021/09/14
Released
(Under revision)
1.1.2
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
2021/01/15
Released
(Under revision)
1.1.1
Paraganglioma development
(GroupA)
Surveillance
(GroupA)
11CB
2019/10/03
Released
(Under revision)
1.1.0
Paraganglioma development
Surveillance
11CB
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
Paraganglioma development
Surveillance
11CB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.1
Paraganglioma development
Surveillance
11CB
Internal system migration related to score text replacement from E to N
2018/03/16
In Preparation
N/A