ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Dilated cardiomyopathy
Gene/Gene Panel: DMD, LMNA, TNNT2
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2026/02/24
Released
3.0.0
A
Heart failure (GroupA)
Surveillance by specialists to guide pharmacotherapy (GroupA) 11NB
Sudden cardiac death (GroupA)
Surveillance by specialists to guide pharmacotherapy (GroupA) 10CB
Surveillance by specialists to guide consideration of implantable cardioverter defibrillator (ICD) (GroupA) 10CB
Major report updates with 10 genes added. New guidelines and evidence since last report.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
DMD ⇔ 0010542 CARDIOMYOPATHY, DILATED, 3B; CMD3B
Strong Actionability
Strong Actionability
LMNA ⇔ 0007269 CARDIOMYOPATHY, DILATED, 1A; CMD1A
Strong Actionability
Strong Actionability
TNNT2 ⇔ 0011095 CARDIOMYOPATHY, DILATED, 1D; CMD1D
Strong Actionability
Strong Actionability
TTN ⇔ 0011400 CARDIOMYOPATHY, DILATED, 1G; CMD1G
Strong Actionability
Strong Actionability
MYH7 ⇔ 0013262 CARDIOMYOPATHY, DILATED, 1S; CMD1S
Strong Actionability
Strong Actionability
FLNC ⇔ 0014883 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 26; CMH26
Strong Actionability
Strong Actionability
BAG3 ⇔ 0013479 CARDIOMYOPATHY, DILATED, 1HH; CMD1HH
Strong Actionability
Strong Actionability
DES ⇔ 0011482 CARDIOMYOPATHY, DILATED, 1I; CMD1I
Strong Actionability
Strong Actionability
SCN5A ⇔ 0011003 CARDIOMYOPATHY, DILATED, 1E; CMD1E
Strong Actionability
Strong Actionability
RBM20 ⇔ 0013168 CARDIOMYOPATHY, DILATED, 1DD; CMD1DD
Strong Actionability
Strong Actionability
TNNC1 ⇔ 0012745 CARDIOMYOPATHY, DILATED, 1Z; CMD1Z
Strong Actionability
Strong Actionability
PLN ⇔ 0012362 CARDIOMYOPATHY, DILATED, 1P; CMD1P
Strong Actionability
Strong Actionability
DSP ⇔ 0014355 CARDIOMYOPATHY, DILATED, WITH WOOLLY HAIR, KERATODERMA, AND TOOTH AGENESIS; DCWHKTA
Strong Actionability
Strong Actionability
2022/03/30
Released (Under revision)
2.1.3
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Internal system migration associated with MONDO name addition.
2022/02/09
Released
2.1.3
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Internal system migration associated with MONDO name addition.
2022/02/09
Released (Under revision)
2.1.2
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Edited MONDO ID
2020/04/29
Released
2.1.2
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Edited MONDO ID
2020/04/29
Released (Under revision)
2.1.1
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Added MONDO IDs and created scoring groups
2020/04/16
Released
2.1.1
A
Earlier heart failure (GroupA)
Surveillance and ACE inhibitors (GroupA) 10BN
Sudden cardiac death (GroupA)
Surveillance and implantable cardiac device (ICD) (GroupA) 9BB
Surveillance and pharmacotherapy (GroupA) 10BN
Added MONDO IDs and created scoring groups
2019/10/03
Released (Under revision)
2.1.0
A
Earlier heart failure
Surveillance and ACE inhibitors 10BN
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BN
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
2.1.0
A
Earlier heart failure
Surveillance and ACE inhibitors 10BN
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BN
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
2.0.2
A
Earlier heart failure
Surveillance and ACE inhibitors 10BN
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BN
Internal system migration related to score text replacement from E to N
2018/01/09
Released
2.0.1
A
Earlier heart failure
Surveillance and ACE inhibitors 10BE
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BE
2017/10/23
Released
2.0.0
A
Earlier heart failure
Surveillance and ACE inhibitors 10BE
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BE
2017/10/23
Released
1.0.2
A
Delay heart failure
Surveillance and ACE inhibitors 10CB
Sudden cardiac death
Surveillance and ICD 10CB
Surveillance and pharmacotherapy 11CC
2017/10/23
Released
1.0.0
A
Earlier heart failure
Surveillance and ACE inhibitors 10BE
Sudden cardiac death
Surveillance and implantable cardiac device (ICD) 9BB
Surveillance and pharmacotherapy 10BE
¤ Powered by BCM's Genboree.