ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Hereditary Breast and Ovarian Cancer
Gene/Gene Panel: BRCA1, BRCA2
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2023/06/28
Released
1.1.6
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Internal system migration to amend the actionability rationale with respect to the assertion, definitive actionability.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
BRCA1 ⇔ 0011450 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
Strong Actionability
Definitive Actionability
BRCA2 ⇔ 0012933 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2; BROVCA2
Strong Actionability
Definitive Actionability
2023/06/28
Released (Under revision)
1.1.5
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
BRCA1 ⇔ 0011450 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
Strong Actionability
Definitive Actionability
BRCA2 ⇔ 0012933 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2; BROVCA2
Strong Actionability
Definitive Actionability
2022/04/19
Released
1.1.5
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
BRCA1 ⇔ 0011450 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
Strong Actionability
Definitive Actionability
BRCA2 ⇔ 0012933 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2; BROVCA2
Strong Actionability
Definitive Actionability
2022/03/07
Released (Under revision)
1.1.4
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Internal system migration associated with MONDO name addition.
2022/02/09
Released
1.1.4
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Internal system migration associated with MONDO name addition.
2022/02/09
Released (Under revision)
1.1.3
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
MONDO added
2020/08/19
Released
1.1.3
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
MONDO added
2020/08/19
Released (Under revision)
1.1.2
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Updated to include a link to the ACMG ACT Sheet. Other parts of the report not updated.
2020/01/31
Released
1.1.2
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
Updated to include a link to the ACMG ACT Sheet. Other parts of the report not updated.
2020/01/31
Released (Under revision)
1.1.1
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
2019/10/08
Released
1.1.1
A
Breast Cancer (BRCA1) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Breast Cancer (BRCA2) (GroupA)
Surveillance (GroupA) 10AA
Mastectomy (GroupA) 9AA
Ovarian Cancer (BRCA1) (GroupA)
Oophorectomy (GroupA) 8AA
Ovarian Cancer (BRCA2) (GroupA)
Oophorectomy (GroupA) 8AA
2019/10/03
Released (Under revision)
1.1.0
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveillance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveillance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.2
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveillance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
Internal system migration related to score text replacement from E to N
2018/04/09
Released
1.0.1
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveillance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
2018/04/09
Released (Under revision)
1.0.0
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveilance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
2017/10/23
Released
1.0.0
A
Breast Cancer (BRCA1)
Mastectomy 9AA
Surveilance 10AA
Breast Cancer (BRCA2)
Mastectomy 9AA
Surveillance 10AA
Ovarian Cancer (BRCA1)
Oophorectomy 8AA
Ovarian Cancer (BRCA2)
Oophorectomy 8AA
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