ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: PALB2-related cancers
Gene/Gene Panel: PALB2
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2025/09/19
Released
2.3.0
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
OMIM and MONDO IDs changed. Old IDs were OMIM 114480 and MONDO 0016419. Recent examination of these IDs reveal that there are new , more appropriate terms available for this topic.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
PALB2 ⇔ 0957530 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 5; BROVCA5
Assertion Pending
Strong Actionability
2025/09/19
Released (Under revision)
2.2.3
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
PALB2 ⇔ 0016419 BREAST CANCER
Moderate Actionability
Strong Actionability
2022/06/21
Released
2.2.3
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
PALB2 ⇔ 0016419 BREAST CANCER
Moderate Actionability
Strong Actionability
2022/03/14
Released (Under revision)
2.2.2
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Internal system migration associated with MONDO name addition.
2022/02/09
Released
2.2.2
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Internal system migration associated with MONDO name addition.
2022/02/09
Released (Under revision)
2.2.1
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
2020/04/27
Released
2.2.1
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
2020/04/27
Released (Under revision)
2.2.0
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/10/03
Released
2.2.0
A
Breast cancer (GroupA)
Chemoprevention (GroupA) 8CB
Mastectomy (GroupA) 8CB
Breast cancer surveillance (GroupA) 9CB
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/04/04
Released
2.1.0
A
Breast cancer
Breast cancer surveillance 9CB
Chemoprevention 8CB
Mastectomy 8CB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
2.0.1
A
Breast cancer
Breast cancer surveillance 9CB
Chemoprevention 8CB
Mastectomy 8CB
Internal system migration related to score text replacement from E to N
2017/10/30
Released
2.0.0
A
Breast cancer
Breast cancer surveillance 9CB
Chemoprevention 8CB
Mastectomy 8CB
2017/09/13
Released
1.0.0
A
Breast cancer
Breast cancer surveillance 9CB
Chemoprevention 8CB
Mastectomy 8CB
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