ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Factor V Leiden, Homozygous (also includes compound heterozygous FVL + prothrombin G20210A)
Gene/Gene Panel: F5
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2022/11/21
Released
1.3.3
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
F5 ⇔ 0008560 THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE; THPH2
Moderate Actionability
Moderate Actionability
2022/03/30
Released (Under revision)
1.3.2
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
Internal system migration associated with MONDO name addition.
2022/02/09
Released
1.3.2
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
Internal system migration associated with MONDO name addition.
2022/02/09
Released (Under revision)
1.3.1
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
2020/04/28
Released
1.3.1
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
2020/04/28
Released (Under revision)
1.3.0
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/10/03
Released
1.3.0
A
VTE (GroupA)
Pharmacological prophylaxis for men and non-pregnant women (GroupA) 6CD
Avoid estrogen-containing compounds that exacerbate VTE risk (GroupA) 9CD
Pharmacological prophylaxis for pregnant women (GroupA) 8CB
Assessment for VTE risk factors (GroupA) IN
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/04/04
Released
1.2.0
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that exacerbate VTE risk 9CD
Pharmacological prophylaxis for men and non-pregnant women 6CD
Pharmacological prophylaxis for pregnant women 8CB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.1.2
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that exacerbate VTE risk 9CD
Pharmacological prophylaxis for men and non-pregnant women 6CD
Pharmacological prophylaxis for pregnant women 8CB
Internal system migration related to score text replacement from E to N
2018/04/09
Released
1.1.1
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that exacerbate VTE risk 9CD
Pharmacological prophylaxis for men and non-pregnant women 6CD
Pharmacological prophylaxis for pregnant women 8CB
2018/04/09
Released (Under revision)
1.1.0
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that excerbate VTE risk 9CD
Pharmacological prophylaxis for men and non-pregnant women 6CD
Pharmacological prophylaxis for pregnant women 8CB
2018/03/19
Released
1.1.0
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that excerbate VTE risk 9CD
Pharmacological prophylaxis for men and non-pregnant women 6CD
Pharmacological prophylaxis for pregnant women 8CB
2018/03/19
Released (Under revision)
1.0.1
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that excerbate VTE risk 10CD
Pharmacological prophylaxis for men and non-pregnant women 7CD
Pharmacological prophylaxis for pregnant women 9CB
2018/01/11
Released
1.0.1
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that excerbate VTE risk 10CD
Pharmacological prophylaxis for men and non-pregnant women 7CD
Pharmacological prophylaxis for pregnant women 9CB
2017/10/23
Released
1.0.0
A
VTE
Assessment for VTE risk factors IN
Avoid estrogen-containing compounds that excerbate VTE risk 10CD
Pharmacological prophylaxis for men and non-pregnant women 7CD
Pharmacological prophylaxis for pregnant women 9CB
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