ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Hereditary Diffuse Gastric Cancer
Gene/Gene Panel: CDH1
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2023/12/20
Released
1.1.4
A
Mortality from breast cancer (GroupA)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupA) 10CC
Risk reducing mastectomy (GroupA) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
Removed older MONDOs and OMIM-MONDO pairs. Replaced with new MONDO that better reflects the full spectrum of the condition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
CDH1 ⇔ 0100488 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC
Assertion Pending
Moderate Actionability
2021/09/03
Released (Under revision)
1.1.3
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
CDH1 ⇔ 0016419 BREAST CANCER
Strong Actionability
Assertion Pending
CDH1 ⇔ 0007648 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC
Moderate Actionability
Assertion Pending
2021/08/19
Released
1.1.3
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
CDH1 ⇔ 0016419 BREAST CANCER
Strong Actionability
Assertion Pending
CDH1 ⇔ 0007648 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC
Moderate Actionability
Assertion Pending
2021/08/19
Released (Under revision)
1.1.2
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
CDH1 ⇔ 0016419 BREAST CANCER
Strong Actionability
Moderate Actionability
CDH1 ⇔ 0007648 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC
Moderate Actionability
Moderate Actionability
2021/08/02
Released
1.1.2
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
CDH1 ⇔ 0016419 BREAST CANCER
Strong Actionability
Moderate Actionability
CDH1 ⇔ 0007648 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC
Moderate Actionability
Moderate Actionability
2021/08/02
Released (Under revision)
1.1.1
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
MONDO IDs added, created scoring groups
2021/01/19
Released
1.1.1
A
Mortality from breast cancer (GroupB)
Imaging surveillance to detect breast cancer and guide initiation of breast cancer treatment (GroupB) 10CC
Risk reducing mastectomy (GroupB) 9CD
Mortality from gastric cancer (GroupA)
Risk reducing gastrectomy (GroupA) 8CB
Endoscopic surveillance to detect gastric cancer or precursors and guide gastric cancer treatment and/or gastrectomy (GroupA) 8CC
MONDO IDs added, created scoring groups
2019/09/28
Released (Under revision)
1.1.0
A
Breast cancer
Risk reducing mastectomy 9CB
Surveillance 10CB
Gastric cancer
Risk reducing gastrectomy 8CA
Surveillance 8CB
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
A
Breast cancer
Risk reducing mastectomy 9CB
Surveillance 10CB
Gastric cancer
Risk reducing gastrectomy 8CA
Surveillance 8CB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.2
A
Breast cancer
Risk reducing mastectomy 9CB
Surveillance 10CB
Gastric cancer
Risk reducing gastrectomy 8CA
Surveillance 8CB
Internal system migration related to score text replacement from E to N
2018/01/11
Released
1.0.1
A
Breast cancer
Risk reducing mastectomy 9CB
Surveillance 10CB
Gastric cancer
Risk reducing gastrectomy 8CA
Surveillance 8CB
2017/10/23
Released
1.0.0
A
Breast cancer
Risk reducing mastectomy 9CB
Surveillance 10CB
Gastric cancer
Risk reducing gastrectomy 8CA
Surveillance 8CB
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