ACTIONABILITY KNOWLEDGE REPOSITORY
ACTIONABILITY CURATION INTERFACE
Update History
Condition: Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1
Gene/Gene Panel: NOTCH3
Context: Adult
2025/02/03
Released
2.0.0
Morbidity and mortality from stroke
(GroupA)
Specialist care and management, including monitoring and controlling vascular risk factors
(GroupA)
8AD
This is a full update of a previously scored gene-condition topic.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
NOTCH3
⇔
0000914 CEREBRAL ARTERIOPATHY, AUTOSOMAL DOMINANT, WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY, TYPE 1; CADASIL1
Moderate Actionability
Limited Actionability
2022/03/30
Released
(Under revision)
1.2.2
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
Internal system migration associated with MONDO name addition.
2022/02/09
Released
1.2.2
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
Internal system migration associated with MONDO name addition.
2022/02/09
Released
(Under revision)
1.2.1
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
MONDO IDs added
2020/05/02
Released
1.2.1
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
MONDO IDs added
2020/05/02
Released
(Under revision)
1.2.0
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/10/03
Released
1.2.0
Stroke
(GroupA)
Specialist care and management
(GroupA)
9CA
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/04/04
Released
1.1.0
Stroke
Specialist care and management
9CA
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.2
Stroke
Specialist care and management
9CA
Internal system migration related to score text replacement from E to N