ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Malignant Hyperthermia Susceptibility
Gene/Gene Panel: RYR1, CACNA1S
Context: Adult
Date
Status
Outcomes-Interventions
Notes
2022/02/09
Released
2.0.1
Malignant hyperthermia event (GroupA)
Awareness of high-risk situations (GroupA) 8CD
Avoidance of triggering anesthetics (GroupA) 11CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RYR1 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1; MHS1
Strong Actionability
Strong Actionability
CACNA1S 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 5
Strong Actionability
Strong Actionability
2022/02/09
Released (Under revision)
2.0.0
Malignant hyperthermia event (GroupA)
Awareness of high-risk situations (GroupA) 8CD
Avoidance of triggering anesthetics (GroupA) 11CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RYR1 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1; MHS1
Strong Actionability
Strong Actionability
CACNA1S 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 5
Strong Actionability
Strong Actionability
2021/05/03
Released
2.0.0
Malignant hyperthermia event (GroupA)
Awareness of high-risk situations (GroupA) 8CD
Avoidance of triggering anesthetics (GroupA) 11CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
RYR1 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1; MHS1
Strong Actionability
Strong Actionability
CACNA1S 0018493 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 5
Strong Actionability
Strong Actionability
2021/03/16
Released (Under revision)
1.1.2
Morbidity from malignant hyperthermia event (GroupA)
Avoidance of triggering anesthetics (GroupA) 10DB
2020/04/22
Released
1.1.2
Morbidity from malignant hyperthermia event (GroupA)
Avoidance of triggering anesthetics (GroupA) 10DB
2020/04/22
Released (Under revision)
1.1.1
Morbidity from malignant hyperthermia event (GroupA)
Avoidance of triggering anesthetics (GroupA) 10DB
Updated to include a link to the ACMG ACT Sheet. Other parts of the report not updated.
2020/01/31
Released
1.1.1
Morbidity from malignant hyperthermia event (GroupA)
Avoidance of triggering anesthetics (GroupA) 10DB
Updated to include a link to the ACMG ACT Sheet. Other parts of the report not updated.
2019/10/03
Released (Under revision)
1.1.0
Morbidity from malignant hyperthermia event
Avoidance of triggering anesthetics 10DB
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
Morbidity from malignant hyperthermia event
Avoidance of triggering anesthetics 10DB
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.1
Morbidity from malignant hyperthermia event
Avoidance of triggering anesthetics 10DB
Internal system migration related to score text replacement from E to N
2018/01/11
Released
1.0.0
Morbidity from malignant hyperthermia event
Avoidance of triggering anesthetics 10DB
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