ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Brugada Syndrome
Gene/Gene Panel: SCN5A
Context: Adult
Date
Status
Release
Outcomes-Interventions
Notes
2022/02/09
Released
2.0.3
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Internal system migration associated with MONDO name addition.
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2022/02/09
Released (Under revision)
2.0.2
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2022/01/14
Released
2.0.2
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2022/01/14
Released (Under revision)
2.0.1
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2021/03/29
Released
2.0.1
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
Assertions
Gene Condition Pairs
Suggested Assertion
Final Assertion
SCN5A ⇔ 0011001 BRUGADA SYNDROME 1; BRGDA1
Strong Actionability
Strong Actionability
2020/12/21
Released (Under revision)
2.0.0
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
2020/05/12
Released
2.0.0
A
Sudden cardiac death (GroupA)
Avoidance of drugs with sodium channel blocking properties and high fever (GroupA) 10CB
2020/04/07
Released (Under revision)
1.2.0
A
Sudden cardiac death (GroupA)
ICD implantation (GroupA) 9CB
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/10/03
Released
1.2.0
A
Sudden cardiac death (GroupA)
ICD implantation (GroupA) 9CB
Internal system migration associated with Gene-Disease scoring groups upgrades.
2019/04/04
Released
1.1.0
A
Sudden cardiac death
ICD
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.3
A
Sudden cardiac death
ICD
Internal system migration related to score text replacement from E to N
2018/01/11
Released
1.0.2
A
Sudden cardiac death
ICD
2017/10/23
Released
1.0.1
A
Sudden cardiac death
ICD
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