ACTIONABILITY KNOWLEDGE REPOSITORY ACTIONABILITY CURATION INTERFACE
Update History
Condition: Hypophosphatasia
Gene/Gene Panel: ALPL
Context: Pediatric
Date
Status
Release
Outcomes-Interventions
Notes
2021/10/18
Released (Under revision)
1.1.2
P
Adverse events (e.g., atypical femoral fractures) (GroupA)
Avoid bisphosphonates (GroupA) 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile) (GroupB)
Enzyme Replacement Therapy (GroupB) 10CC
Rickets/fractures (GroupA)
Enzyme Replacement Therapy (GroupA) 7CC
2020/04/16
Released
1.1.2
P
Adverse events (e.g., atypical femoral fractures) (GroupA)
Avoid bisphosphonates (GroupA) 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile) (GroupB)
Enzyme Replacement Therapy (GroupB) 10CC
Rickets/fractures (GroupA)
Enzyme Replacement Therapy (GroupA) 7CC
2020/04/16
Released (Under revision)
1.1.1
P
Adverse events (e.g., atypical femoral fractures) (GroupA)
Avoid bisphosphonates (GroupA) 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile) (GroupB)
Enzyme Replacement Therapy (GroupB) 10CC
Rickets/fractures (GroupA)
Enzyme Replacement Therapy (GroupA) 7CC
Added MONDO IDs and created scoring groups
2020/04/16
Released
1.1.1
P
Adverse events (e.g., atypical femoral fractures) (GroupA)
Avoid bisphosphonates (GroupA) 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile) (GroupB)
Enzyme Replacement Therapy (GroupB) 10CC
Rickets/fractures (GroupA)
Enzyme Replacement Therapy (GroupA) 7CC
Added MONDO IDs and created scoring groups
2019/10/03
Released (Under revision)
1.1.0
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile)
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
Internal system migration related to merging adult and pediatric contexts.
2019/04/04
Released
1.1.0
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile)
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
Internal system migration related to merging adult and pediatric contexts.
2018/11/01
Released
1.0.2
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile)
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
Internal system migration related to score text replacement from E to N
2018/10/05
Released
1.0.1
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death (infantile)
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
2018/10/05
Released (Under revision)
1.0.0
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
2018/10/05
Released
1.0.0
P
Adverse events (e.g., atypical femoral fractures)
Avoid bisphosphonates 4DD
Respiratory failure that can lead to long-term ventilatory support or death
Enzyme Replacement Therapy 10CC
Rickets/fractures
Enzyme Replacement Therapy 7CC
2018/09/10
In Preparation
N/A
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