Stage I: Rule-Out Dashboard Secondary Findings in Adults Stage II Report Update History Status (Adult):Passed (Actionability assessment is indicated.)

GENE/GENE PANEL:
F5
HGNC IDs:
HGNC:3542
DISORDER:
Factor V Leiden, Heterozygous
OMIM IDs:
188055
ACTIONABILITY
1. Is there a qualifying resource, such as a practice guideline or systematic review, for the genetic condition?
YES
NO
2. Does the practice guideline or systematic review indicate that the result is actionable in one or more of the following ways?
YES
NO
Patient Management
Surveillance or Screening
Family Management
Circumstances to Avoid
YES (>= 1 above)
NO (STOP)
3. Is the result actionable in an undiagnosed adult with the genetic condition?
YES
NO (STOP)
PENETRANCE
4. Is there at least one known pathogenic variant with at least moderate penetrance (≥40%) or moderate relative risk (≥2) in any population?
YES
NO
UNKNOWN
SIGNIFICANCE/BURDEN OF DISEASE
5. Is this condition an important health problem?
YES
NO
6. Are Actionability (Q2-3), Penetrance (Q4), and Significance (Q5) all "YES"?
YES (Proceed to Stage - II)
NO (Consult Actionability Working Group)
Exception granted, proceed to Stage II
Exception not granted, STOP
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